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- Title
Association of β-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population.
- Authors
Bi, Y.; Zeng, L.; Zhu, D.; Yan, J.; Zhang, Y.; Tong, G.; Mu, P.; Shen, S.; Hu, Y.; Yu, Q.; Liang, H.; Weng, J.
- Abstract
Aim: Our aim was to provide a quantitative analysis of the changes in the principal determinants of insulin sensitivity and secretion in relation to fasting plasma glucose (FPG) or 2-h plasma glucose (2h PG) in a Chinese population with a wide range of glucose tolerance. Methods: A total of 5728 adults spanning the entire range of glucose tolerance were included. Insulin sensitivity was measured by Matsuda insulin sensitivity index (ISIM) and homeostasis model assessment of 1/homeostasis model assessment of insulin resistance (HOMA-IR). β-Cell function adjusted by insulin sensitivity was assessed from disposition index (DI) at early-phase DI30 and total DI120. The exponential curve was established as the best fit for the relationship between insulin sensitivity or β-cell function and FPG or 2h PG. Results: Relative to the trend classified as increasing 2h PG, hepatic insulin sensitivity and insulin secretion showed a decreasing trend to a substantial degree as FPG increased. A 1 mmol/l increase in FPG and 2h PG concentration was associated with a −22 and −21% decline in ISIM, −16 and −4% in 1/HOMA-IR, −38 and −35% in DI30 and −36 and −26% in DI120. The decay constant of ISIM and DI30 in IFG or ISIM, 1/HOMA-IR, DI30 and DI120 in IGT was lower than that in normal glucose tolerance. Significant interactions between sex and glucose levels determining DI were found. Conclusions: We conclude that impairment of insulin sensitivity and insulin secretion contributes to both FPG or 2h PG hyperglycaemia in a Chinese population, but that the decline in insulin secretion is more pronounced with increasing fasting than 2h PG.
- Subjects
CHINA; PANCREATIC beta cells; INSULIN resistance; TYPE 2 diabetes; QUANTITATIVE research
- Publication
Diabetes, Obesity & Metabolism, 2012, Vol 14, Issue 2, p174
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2011.01504.x