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- Title
Low-target tacrolimus in de novo standard risk renal transplant recipients: A single-centre experience.
- Authors
Størset, Elisabet; Åsberg, Anders; Hartmann, Anders; Reisæter, Anna V.; Holdaas, Hallvard; Skauby, Morten; Bergan, Stein; Midtvedt, Karsten
- Abstract
Aim Optimal tacrolimus exposure in transplant recipients is not well established. The results from the Symphony study indicated that low-target tacrolimus (trough concentrations 3-7 µg/L) in de novo standard risk renal transplant recipients should be appropriate. The aim of this study was to evaluate real-life outcomes when applying a similar strategy in a clinical setting. Methods A single-centre analysis was conducted in standard risk renal transplant recipients receiving low-target tacrolimus, mycophenolate mofetil, glucocorticoids and basiliximab induction. One-year estimated glomerular filtration rate (eGFR, Cockcroft-Gault), one-year biopsy-proven acute rejection rate and graft- and patient survival up to 3 years post-transplant were compared with the outcomes in the Symphony study. Results From 1 January 2009 to 31 March 2013, we included 406 patients. One year after transplantation, the mean ± SD eGFR was 76.8 ± 28.3 mL/min (Symphony: 65.4 ± 27.0 mL/min, P < 0.001). Biopsy-proven acute rejections were seen in 14.5% of the patients (Symphony: 12.3%, P = 0.35). Kaplan-Meier estimates [95% confidence interval] of three-year death-censored graft- and patient survival were 96.6% [94.2-99.0%] (Symphony: 93%) and 95.0% [92.6-97.3%] (Symphony: 95%), respectively. Conclusion Low-target tacrolimus-based immunosuppression is safe and effective also in a standard clinical setting in de novo standard risk renal transplant recipients.
- Subjects
KIDNEY transplantation; TACROLIMUS; IMMUNOSUPPRESSION; CALCINEURIN; GLOMERULAR filtration rate
- Publication
Nephrology, 2016, Vol 21, Issue 10, p821
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.12738