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- Title
Relationship between β1-adrenergic receptor polymorphisms and cardiovascular disease in patients with diabetic nephropathy.
- Authors
PETER YAM-KAU POON; CHEUK-CHUN SZETO; BONNIE CHING-HA KWAN; KAI-MING CHOW; PHILIP KAM-TAO LI
- Abstract
Aim: Activation of β1-adrenergic receptor (β1AR) enhances contractility and heart rate. The polymorphism Arg389Gly in the β 1AR gene was found to be functionally important in determining receptor activity. The relationship between this polymorphism and the risk of cardiovascular disease was investigated in Chinese subjects with overt diabetic nephropathy. Methods: A total of 219 type 2 diabetic subjects with nephropathy were recruited. Genotyping of the β 1AR Arg389Gly polymorphism was determined. Patients were followed up to 96 months for the development of cardiovascular events. Results: There were 122, 86 and 11 patients with Arg/Arg, Arg/Gly and Gly/Gly genotype, respectively. At 96 months, the event-free survival of primary composite cardiovascular end-point was 33.0% and 44.3% for Gly+ and Gly- groups, respectively (log–rank test, P = 0.105), while the event-free survival for first ischaemic heart disease was 62.4% and 75.9%, respectively (log–rank test, P = 0.038). However, with multivariate analysis by the Cox proportional hazard model to adjust for confounders, only low-density lipoprotein and baseline glomerular filtration rate were independent predictors of first ischaemic heart event. Conclusion: The β 1AR Arg389Gly polymorphism is not an independent predictor of cardiovascular events in subjects with overt diabetic nephropathy.
- Subjects
BETA adrenoceptors; ADRENERGIC receptors; ISOHORMONES; CARDIOVASCULAR diseases; PATIENTS; SYMPATHETIC nervous system; CHRONIC kidney failure; KIDNEY diseases; CORONARY disease
- Publication
Nephrology, 2010, Vol 15, Issue 2, p242
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2009.01182.x