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- Title
Positive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population.
- Authors
CHEUNG, T. K.; LAM, K. F.; HU, W. H. C.; LAM, C. L. K.; WONG, W. M.; HUI, W. M.; LAI, K. C.; LAM, S. K.; WONG, B. C. Y
- Abstract
Background Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases which may be related. Aim To examine the association between gastro-oesophageal reflux disease and irritable bowel syndrome in Chinese population in Hong Kong. Methods Randomly selected ethnic Chinese were invited to participate in a telephone survey in 1996. Gastro-oesophageal reflux disease was defined as subjects having heartburn and/or acid regurgitation once weekly or more. Irritable bowel syndrome was diagnosed according to the Rome I criteria. The association between gastro-oesophageal reflux disease and irritable bowel syndrome was calculated using a statistical model which allows the odds ratio to be measured. Results One thousand six hundred and forty-nine subjects completed the interview (response rate 62%). The population prevalence of gastro-oesophageal reflux disease and irritable bowel syndrome were 5% and 4%, respectively. Thirteen per cent of subjects with gastro-oesophageal reflux disease and 11% with irritable bowel syndrome suffered from both gastro-oesophageal reflux disease and irritable bowel syndrome. The OR of having gastro-oesophageal reflux disease and irritable bowel syndrome together was estimated to be 3 (95% CI: 1.05, 6.27) indicating a positive association between the two diseases. This association occurred predominantly in male subjects [OR = 9.3, (95% CI: 2.3, 26.2)] but not as strong in females [OR = 1.5, (95% CI: 0.3, 4.3)]. Younger subjects were statistically more prone to the two diseases. Conclusions There is a positive association between gastro-oesophageal reflux disease and irritable bowel syndrome, and their association occurs predominantly in male subjects.
- Subjects
HONG Kong (China); GASTROESOPHAGEAL reflux; IRRITABLE colon; TELEPHONE surveys; CHINESE people
- Publication
Alimentary Pharmacology & Therapeutics, 2007, Vol 25, Issue 9, p1099
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2007.03304.x