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- Title
Malignant Phyllodes Tumor of the Breast: A Practice Review.
- Authors
de Souza Fede, Ângelo Bezerra; Pereira Souza, Ronaldo; Doi, Mauricio; De Brot, Marina; Bueno de Toledo Osorio, Cynthia Aparecida; Melo Gondim, Guilherme Rocha; Claudio Casali-da-Rocha, Jose; Jbili, Rima; Vieira Bitencourt, Almir Galvao; Alves de Souza, Juliana; Caparica Bitton, Rafael; Alves Makdissi, Fabiana Baroni; Moraes Sanches, Solange
- Abstract
Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy. Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor. Conclusions: mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors.
- Subjects
PHYLLODES tumors; BREAST tumors; BREAST cancer; ONCOLOGIC surgery; PATIENT preferences; DIAGNOSIS
- Publication
Clinics & Practice, 2021, Vol 11, Issue 2, p205
- ISSN
2039-7283
- Publication type
Article
- DOI
10.3390/clinpract11020030