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- Title
Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study).
- Authors
Hümmert, Martin W; Stern, Carlotta; Paul, Friedemann; Duchow, Ankelien; Bellmann-Strobl, Judith; Ayzenberg, Ilya; Schwake, Carolin; Kleiter, Ingo; Hellwig, Kerstin; Jarius, Sven; Wildemann, Brigitte; Senel, Makbule; Berthele, Achim; Giglhuber, Katrin; Luessi, Felix; Grothe, Matthias; Klotz, Luisa; Schülke, Rasmus; Gingele, Stefan; Faiss, Jürgen H
- Abstract
Background: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). Objective: To assess cognitive performance and changes over time in NMOSD. Methods: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. Results: NMOSD patients were impaired in SDMT (p = 0.007), MuSIC semantic fluency (p < 0.001), and MuSIC congruent speed (p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability (p Bon < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. Conclusions: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.
- Subjects
NEUROMYELITIS optica; COGNITIVE processing speed; COGNITION; COGNITIVE testing; COGNITIVE ability
- Publication
Multiple Sclerosis Journal, 2023, Vol 29, Issue 7, p819
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585231151212