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- Title
Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study.
- Authors
Seung-Hwan Lee; Hyuk-Sang Kwon; Yong-Moon Park; Seung-Hyun Ko; Yoon-Hee Choi; Kun-Ho Yoon; Yu-Bae Ahn
- Abstract
Background: This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD). Methods: Ninety-nine subjects on rosuvastatin treatment and whose LDL-C level was lower than 100 mg/dL were randomly assigned to discontinue or maintain statin treatment at a 2:1 ratio. The subjects were followed-up after 10 weeks. A relapse of dyslipidemia was defined as a reascent of LDL-C level to greater than 100 mg/dL. Results: The statin discontinuation group had a significant rate of relapse compared to the maintenance group (79% vs. 3%, respectively). Pretreatment and baseline lipid levels, their ratios, and hemoglobin A1c level were significantly different between the relapse and nonrelapse groups. The pretreatment and baseline lipid profiles and their ratios were independently associated with relapse. The pretreatment LDL-C level was the most useful parameter for predicting a relapse, with a cutoff of 123 mg/dL. During the follow-up period, no CVD event was noted. Conclusion: The relapse rate of dyslipidemia was high when statins were discontinued in type 2 diabetic patients without CVD. Statin discontinuation should be considered carefully based on the pretreatment lipid profiles of patients.
- Subjects
DYSLIPIDEMIA; STATINS (Cardiovascular agents); LOW density lipoproteins; PEOPLE with diabetes; DISEASE relapse; HEMOGLOBINS
- Publication
Diabetes & Metabolism Journal, 2014, Vol 38, Issue 1, p64
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2014.38.1.64