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- Title
A Macrocyclic Tweezers‐Shaped Receptor for the Biomimetic Recognition of the Gal(α1‐3)Gal Disaccharide of the α‐Gal Antigen.
- Authors
Milanesi, Francesco; Burrini, Nastassja; Corti, Giona; Roelens, Stefano; Francesconi, Oscar
- Abstract
The Gal(α1‐3)Gal is the terminal disaccharide unit of the α‐Gal epitope [Gal(α1‐3)Gal(β1‐4)GlcNAc], an exogenous antigenic determinant with several clinical implications, found in all non‐primate mammals and in several dangerous pathogens, including certain protozoa and mycobacteria. Its absence in humans makes the α‐Gal epitope an interesting target for several infectious diseases. Here we present the development of a macrocyclic tweezers‐shaped receptor, resulting from the combination of the structural features of two predecessors belonging to the family of diaminocarbazole receptors, which exhibits binding properties in the low millimolar range toward the Gal(α1‐3)Gal disaccharide of the α‐Gal antigen.
- Subjects
EPITOPES; SYNTHETIC receptors; MOLECULAR recognition; DISACCHARIDES; COMMUNICABLE diseases
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 43, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202401771