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- Title
Expression of MicroRNA-224-3p in vitiligo.
- Authors
El-Rifaie, Abd-El Aziz; Naguib, Rehab Mohamed; Ibrahim, Hanan Ahmed; Rashed, Laila Ahmed
- Abstract
Background Vitiligo is a skin and less common hair disease characterized by decline melanocytes function and depigmentation with a prevalence of 0.5-1% in most populations. MicroRNAs (miRNAs) are small single stranded; approximately 22 nucleotide-long, non-coding generegulatory RNA molecules that inhibit gene expression through translational repression or mRNA turnover. Objective This case control study aimed at detection of the expression of microRNA-224-3p in lesional skin of vitiligo patients as compared to normal control persons to detect the possible role of microRNA-224-3p in the pathogenesis of vitiligo. Methods This study included 60 patients with vitiligo and 60 age, gender matched healthy controls. 4 mm punch skin biopsy had been taken from patients (vitiligo lesion) & controls and it had been kept in lysis solution for the stability of the studied parameters and was kept frozen at - 80 Celsius till analysis of microRNA-224-3p by qRT PCR. Results The level of microRNA-224-3p in lesional skin of vitiligo was significantly higher as compared to normal control persons.
- Subjects
VITILIGO; HAIR diseases; NON-coding RNA; SKIN biopsy
- Publication
Journal of Pakistan Association of Dermatologists, 2021, Vol 31, Issue 4, p680
- ISSN
1560-9014
- Publication type
Case Study