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- Title
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide.
- Authors
Shi, Tengfei; Guo, Dianhao; Zheng, Yaoqiang; Wang, Wenbin; Bi, Jinfang; He, Anshun; Fan, Sibo; Su, Guangsong; Zhao, Xueyuan; Zhao, Zhenhao; Song, Yingjie; Sun, Shupeng; Li, Peng; Zhao, Zhongfang; Shi, Jiandang; Lu, Wange; Zhang, Lei
- Abstract
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modulate TMZ sensitivity via regulation of SORBS2 and DDR1 genes by super-enhancer RNA LINC02454. We report that LINC02454 activity increases glioma cell TMZ sensitivity by maintaining long-range chromatin interactions between SORBS2 and the LINC02454 enhancer. By contrast, LINC02454 activity also decreased glioma cell TMZ sensitivity by promoting DDR1 expression. Our study suggests a bivalent function for super-enhancer RNA LINC02454 in regulating glioma cell sensitivity to TMZ.
- Publication
Cell Death & Disease, 2024, Vol 15, Issue 1, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-023-06392-w