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- Title
Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion.
- Authors
Quadri, Syed; Jackson, Debra W.; Prathipati, Priyanka; Dean, Courtney; Jackson, Keith E.
- Abstract
Purpose. Studies were performed to examine hemodynamic and renal function before and after acute induction of the endogenous CO system with delta-aminolevulinic acid (DALA), which drives HO activity. Methods. In vivo studies were conducted on Inactinanesthetized male Sprague Dawley rats (250-300 g) either with or without chronic pretreatment with L-NAME (50mg/Kg, q12 hours x4d). Results. DALA (80μmol/Kg, IV bolus) administration acutely increased endogenous CO production and HO-1 protein. In untreated and L-NAME-pretreated rats, DALA did not alter BP, GFR, or RBF but increased UF, UNaV, and UKV (untreated: Δ108.8 ± 0.28%, 172.1 ± 18.4%, and 165.2 ± 45.9%; pretreated: Δ109.4 ± 0.29%, 187.3 ± 26.9%, and 197.2 ± 45.7%). Acute administration of biliverdin (20mg/kg, IV) and bilirubin (30mg/kg, IV) to similarly treated animals did not alter UF, UNaV, and UKV. Conclusion. These results demonstrate that heme oxygenase induction increases urine and electrolyte excretion and suggest a direct tubular action of endogenous carbon monoxide.
- Subjects
ACADEMIC medical centers; AMINO acids; ANIMAL experimentation; CARBON monoxide; ELECTROLYTES; GLOMERULAR filtration rate; HEME; METABOLISM; PHARMACOLOGY; RATS; RENIN; WATER; DATA analysis; CONTROL groups; DESCRIPTIVE statistics
- Publication
International Journal of Hypertension, 2012, p1
- ISSN
2090-0384
- Publication type
Article
- DOI
10.1155/2012/690973