We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Haplotype of ESR1 and PPARD Genes Is Associated with Higher Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary Factors—An 18-Month Follow-Up.
- Authors
Huang, Yu-Min; Wang, Weu; Hsieh, Po-Pin; Chen, Hsin-Hung
- Abstract
The obesity genetic effect may play a major role in obesogenic environment. A combined case–control and an 18-month follow-up were carried out, including a total of 311 controls and 118 obese cases. All participants were aged in the range of 20–55 y/o. The body mass index (BMI) of obese cases and normal controls was in the range of 27.0–34.9 and 18.5–23.9 kg/m2, respectively. The rs712221 on Estrogen receptor1 (ESR1) and rs2016520 on Peroxisome proliferator–activated receptor delta (PPARD) showed significant associations with obesity. The TT (odds ratio (OR): 2.42; 95% confidence interval (CI): 1.46–4.01) and TT/TC (OR: 2.80; 95% CI: 1.14–6.85) genotypes on rs712221 and rs2016520 had significantly higher obesity risks, respectively. Moreover, the synergic effect of these two risk SNPs (2-RGH) exhibited an almost geometrical increase in obesity risk (OR: 7.00; 95% CI: 2.23–21.99). Obese individuals with 2-RGH had apparently higher changes in BMI increase, body weight gain and dietary fiber intake but a lower total energy intake within the 18-month follow-up.
- Subjects
OBESITY risk factors; DIETARY fiber; ENERGY metabolism; GENETICS; CONFIDENCE intervals; ANTHROPOMETRY; PEROXISOME proliferator-activated receptors; DIET; CASE-control method; RISK assessment; ESTROGEN receptors; WEIGHT gain; HAPLOTYPES; GENES; DESCRIPTIVE statistics; BODY mass index; ODDS ratio; LONGITUDINAL method
- Publication
Nutrients, 2022, Vol 14, Issue 20, p4425
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14204425