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- Title
Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise.
- Authors
Martin-Rincon, Marcos; Gelabert-Rebato, Miriam; Galvan-Alvarez, Victor; Gallego-Selles, Angel; Martinez-Canton, Miriam; Lopez-Rios, Laura; Wiebe, Julia C.; Martin-Rodriguez, Saul; Arteaga-Ortiz, Rafael; Dorado, Cecilia; Perez-Regalado, Sergio; Santana, Alfredo; Morales-Alamo, David; Calbet, Jose A L
- Abstract
Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.
- Subjects
SKELETAL muscle physiology; ANTIOXIDANTS; DIETARY supplements; JUMPING; LEAVES; MEDICINAL plants; MYALGIA; MYOGLOBIN; POLYPHENOLS; QUERCETIN; RUNNING; STATISTICAL sampling; SERUM; PLANT extracts; ALANINE aminotransferase; COOLDOWN; ERGOGENIC aids; RANDOMIZED controlled trials; BLIND experiment; SKELETAL muscle; DESCRIPTIVE statistics
- Publication
Nutrients, 2020, Vol 12, Issue 3, p614
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12030614