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- Title
High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease.
- Authors
Aisen, Paul S.; Schneider, Lon S.; Sano, Mary; Diaz-Arrastia, Ramon; van Dyck, Christopher H.; Weiner, Myron F.; Bottiglieri, Teodoro; Jin, Sheila; Stokes, Karen T.; Thomas, Ronald G.; Thal, Leon J.
- Abstract
The article presents a randomized controlled trial designed to determine the efficacy and safety of treating Alzheimer's disease with high-dose B vitamins. The outcome was measured using the cognitive subscale of the Alzheimer Disease Assessment Scale at 18 months. It was reported that homocysteine levels were reduced but that the vitamins did not slow cognitive decline in patients with mild to moderate Alzheimer's disease. The methods, statistical analysis and list of adverse events is included.
- Subjects
RANDOMIZED controlled trials; ALZHEIMER'S disease research; VITAMIN B12; VITAMIN B6; COGNITIVE analysis; HOMOCYSTEINE
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 300, Issue 15, p1774
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.300.15.1774