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- Title
Efficacy and Safety of Incretin Therapy in Type 2 Diabetes.
- Authors
Amori, Renee E.; Lau, Joseph; Pittas, Anastassios G.
- Abstract
This article presents a review and meta-analysis on the efficacy and safety of incretin therapy in type 2 diabetes. The efficacy of available therapies diminishes as the disease progresses because of a steady decline in pancreatic beta cell function. Research into the incretin effect on the pathophysiology of type 2 diabetes has led to the development of different hypoglycemic agents. This paper seeks to assess the efficacy and safety of this therapy on adults with type 2 diabetes. The analysis showed that incretin therapy is an alternative option for nonpregnant adults, has modest efficacy and a favorable weight-change profile. The authors caution that further testing is needed to determine the role of this class of drugs.
- Subjects
TREATMENT of diabetes; PANCREATIC beta cells; HYPOGLYCEMIC agents; META-analysis; CLINICAL drug trials; CLINICAL trials; HEALTH outcome assessment
- Publication
JAMA: Journal of the American Medical Association, 2007, Vol 298, Issue 2, p194
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.298.2.194