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- Title
Fatal hepatic necrosis due to pyrimethamine-sulfadoxine (Fansidar).
- Authors
Zitelli, Basil J.; Alexander, Jeffrey; Taylor, Suzanne; Miller, Kirk D.; Howrie, Denise L.; Kuritsky, Joel N.; Perez, Thomas H.; Van Thiel, David H.; Zitelli, B J; Alexander, J; Taylor, S; Miller, K D; Howrie, D L; Kuritsky, J N; Perez, T H; Van Thiel, D H
- Abstract
Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.
- Subjects
LIVER failure; AMINOTRANSFERASES; DRUG interactions; ASPARTATE aminotransferase; HEPATOTOXICOLOGY
- Publication
Annals of Internal Medicine, 1987, Vol 106, Issue 3, p393
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-106-3-393