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- Title
Nonresponsiveness to hepatitis B vaccine in health care workers. Results of revaccination and genetic typings.
- Authors
Craven, Donald E.; Awdeh, Zuheir L.; Kunches, Laureen M.; Yunis, Edmond J.; Dienstag, Jules L.; Werner, Barbara G.; Polk, B. Frank; Snydman, David R.; Platt, Richard; Crumpacker, Clyde S.; Grady, George F.; Alper, Chester A.; Craven, D E; Awdeh, Z L; Kunches, L M; Yunis, E J; Dienstag, J L; Werner, B G; Polk, B F; Syndman, D R
- Abstract
Twenty-eight health care workers who had a poor antibody response when initially vaccinated with hepatitis B vaccine were revaccinated with three additional 20-microgram doses. Eight of the twenty nonresponders, who had levels of antibody to hepatitis B surface antigen (anti-HBs) of less than 8 estimated radioimmunoassay (RIA) units, and all 8 of the hyporesponders, who had anti-HBs levels of 8 or 16 RIA units, attained anti-HBs levels of 36 RIA units or more after revaccination. Tests for HLA-A, B, C, and DR; for complement proteins C2, C4A, C4B, and BF; and for the erythrocyte enzyme glyoxalase I were done in 17 nonresponders and 3 hyporesponders. Nine (45%) had HLA-DR7 and 8 (40%) had HLA-DR3, compared with an expected rate of 23% in the general population. At least one of two extended haplotypes (B44, DR7, FC31 or B8, DR3, SCO1) were detected in 6 of the 9 who did not respond to revaccination, compared with 2 of 11 who responded to a second course of vaccine. Poor responders to vaccine may benefit from revaccination, and genetic factors may modulate the immune response to vaccination.
- Subjects
HEPATITIS B vaccines; HEPATITIS B virus; MEDICAL personnel
- Publication
Annals of Internal Medicine, 1986, Vol 105, Issue 3, p356
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-105-3-356