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- Title
Peripapillary and macular choroidal area in patients with normal-tension glaucoma.
- Authors
Kojima, Hirokazu; Hirooka, Kazuyuki; Nitta, Eri; Sonoda, Shozo; Sakamoto, Taiji
- Abstract
Purpose: To evaluate normal and normal-tension glaucoma (NTG) eyes for differences in peripapillary and macular choroidal area measurements. Methods: This cross-sectional comparative study enrolled 52 normal subjects and 35 NTG patients. Peripapillary and macular choroidal images were recorded by enhanced depth imaging optical coherence tomography (EDI-OCT), with conversion of the luminal and interstitial areas to binary images performed using the Niblack method. Results: While there was a significant difference between normal subjects and NTG patients for the peripapillary choroidal area (1,853,672 ± 626,501 μm2 vs. 1,606,448 ± 418,214 μm2, P = 0.047), there were no significant differences between the normal subjects and NTG patients observed for the macular choroidal area (345,365 ± 119,248 μm2 vs. 316,442 ± 85,732 μm2, P = 0.23). In the NTG patients, multivariate regression analysis demonstrated a correlation between the macular choroidal area and the axial length (β = -0.345, P = 0.04). Furthermore, there was also a significant correlation between the peripapillary choroidal area and the age of the NTG patients (β = -0.469, P = 0.004). In addition, there was no relationship between the glaucoma severity and the peripapillary and macular choroidal areas in the NTG patients. Conclusions: There was no correlation between the peripapillary choroidal area and glaucoma severity in NTG patients, even though the area was smaller in these patients.
- Subjects
GLAUCOMA diagnosis; CHOROID; OPTICAL coherence tomography; CROSS-sectional method; COMPARATIVE studies
- Publication
PLoS ONE, 2018, Vol 13, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0204183