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- Title
Sex Steroid Hormones, Growth and Puberty in Children with Portal Hypertension.
- Authors
Yuse-Gabriel, Cynthia M.; Shneider, Benjamin L.; Daum, Fredric; Doug Yoon; Sison, Cristina P.; Speiser, Phyllis W.
- Abstract
Perturbations in sex hormones occur in adults with liver disease; however, little is known about how liver disease affects hormone levels in children. To address this issue, we recruited 19 patients with portal hypertension and 21 non-hormone-deficient short children as controls. Serum sex hormones, sex hormone binding globulin (SHBG), IGF-I, IGFBP-3, gonadotropins, and thyroid hormones were measured; growth and pubertal status were recorded. There was no significant difference between groups for any of the sex hormones, SHBG, gonadotropins, or thyroid hormones. In contrast, IGF-I and IGFBP-3 were significantly lower among patients than controls, despite the fact that height SDS for the control group was significantly lower. We conclude from this crosssectional study that children with portal hypertension do not have clinical evidence of growth failure or abnormal puberty, despite subtle changes in the growth axis.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2004, Vol 17, Issue 4, p607
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2004.17.4.607