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- Title
Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug.
- Authors
Inoue, Kazunori; Nagasawa, Yasuyuki; Yamamoto, Ryohei; Omori, Hiroki; Kimura, Tomonori; Tomida, Kodo; Furumatsu, Yoshiyuki; Imai, Enyu; Isaka, Yoshitaka; Rakugi, Hiromi
- Abstract
S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the urine. We describe a 35-year-old man with acute kidney injury while taking S-1 and cisplatin for advanced gastric cancer and who presented severe adverse effects of 5-FU. This case report describes the evolution of the plasma concentrations of 5-FU with haemodialysis along with a decrease in the adverse drug effects.
- Subjects
CISPLATIN; GASTRIC mucosa; CANCER chemotherapy; FLUOROURACIL; HEMODIALYSIS; CANCER
- Publication
NDT Plus, 2009, Vol 2, Issue 2, p152
- ISSN
1753-0784
- Publication type
Article
- DOI
10.1093/ndtplus/sfn195