We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.
- Authors
Levy, Bruno; Mansart, Arnauld; Montemont, Chantal; Gibot, Sebastien; Mallie, Jean-Pierre; Regnault, Veronique; Lecompte, Thomas; Lacolley, Patrick
- Abstract
<bold>Objective: </bold>We examined whether lactate availability is a limiting factor for heart function during endotoxic shock, and whether lactate deprivation thus induces heart energy depletion, thereby altering cardiovascular performance. The study goals were to determine whether muscle lactate production is linked to beta(2)-stimulation and to ascertain the effects of systemic lactate deprivation on hemodynamics, lactate metabolism, heart energetics, and outcome in a lethal model of rat's endotoxic shock.<bold>Interventions: </bold>We modulated the adrenergic pathway in skeletal muscle using microdialysis with ICI-118551, a selective beta(2)-blocker. Muscle lactate formation in endotoxic shock was further inhibited by intravenous infusion of ICI-118551 or dichloroacetate (DCA), an activator of pyruvate dehydrogenase (DCA) and their combination.<bold>Results: </bold>Muscle lactate formation was decreased by ICI-118551. During endotoxic shock both ICI-118151 and DCA decreased circulating and heart lactate concentrations in parallel with a decrease in tissue ATP content. The combination ICI-118551-DCA resulted in early cardiovascular collapse and death. The addition of molar lactate to ICI-1185111 plus DCA blunted the effects of ICI-118551+DCA on hemodynamics. Survival was markedly less with ICI-118551 than with endotoxin alone.<bold>Conclusion: </bold>Systemic lactate deprivation is detrimental to myocardial energetics, cardiovascular performance, and outcome.
- Subjects
SEPTIC shock; LACTATES; HEMODYNAMICS; CARDIOVASCULAR system; HEART metabolism; MYOCARDIUM; ADRENALINE; ANALYSIS of variance; ANIMAL experimentation; CELL receptors; CORONARY circulation; ENERGY metabolism; GLYCOLYSIS; LACTIC acid; RATS; SURVIVAL analysis (Biometry)
- Publication
Intensive Care Medicine, 2007, Vol 33, Issue 3, p495
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-006-0523-9