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- Title
Enhanced Liver Fibrosis Score Stratifies Hepatocellular Carcinoma Risk in Patients With Hepatitis B Surface Antigen Seroclearance.
- Authors
Mak, Lung-Yi; Cheung, Ka-Shing; Hui, Rex Wan-Hin; Wong, Danny Ka-Ho; Fung, James; Yuen, Man-Fung; Seto, Wai-Kay
- Abstract
In this prospective study involving 337 chronic hepatitis B patients who achieved spontaneous hepatitis B surface antigen (HBsAg) seroclearance (SC), serum enhanced liver fibrosis (ELF) before SC was associated with hepatocellular carcinoma (HCC) (hazard ratio 2.588), and ELF <10.8 was associated with >97% reduction in risk of HCC development in patients with age SC ≥ 50 (n = 190).
- Subjects
VIRAL antigens; STATISTICS; LIVER tumors; DNA; CONFIDENCE intervals; PREDICTIVE tests; CIRRHOSIS of the liver; HEPATITIS viruses; RETROSPECTIVE studies; BLOOD collection; IMMUNOMODULATORS; RISK assessment; COMPARATIVE studies; DESCRIPTIVE statistics; SURVIVAL analysis (Biometry); HEPATOCELLULAR carcinoma; CHRONIC hepatitis B; LONGITUDINAL method; DISEASE risk factors; EVALUATION; DISEASE complications
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 12, p2257
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac387