We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Diversity of IL-17-producing T lymphocytes.
- Authors
Kim, Jiyeon; Jordan, Martha
- Abstract
Interleukin (IL)-17 is a pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi and also in the pathogenesis of autoimmune diseases. While CD4+ TCRαβ+ T helper (Th) 17 cells are the best-described cellular source of IL-17, many innate-like T cells are in fact potent producers of IL-17. Given the increasing interest in therapeutic modulation of the IL-17 axis, it is crucial to better understand the cellular origins of IL-17 in various infection and diseases settings. While the diverse population of IL-17-producing T cells share many common characteristics, notable differences also exist. In this review, we discuss the heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function.
- Subjects
AUTOIMMUNE disease treatment; T cells; INTERLEUKIN-17; CYTOKINES; T helper cells; THERAPEUTICS; EXTRACELLULAR matrix
- Publication
Cellular & Molecular Life Sciences, 2013, Vol 70, Issue 13, p2271
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-012-1163-6