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- Title
Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis.
- Authors
Mohammadi, Amir Saeid; Fletcher, John S.; Malmberg, Per; Ewing, Andrew G.
- Abstract
To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M + H]+ ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode. Copyright © 2014 John Wiley & Sons, Ltd.
- Subjects
SILVER nanoparticles; GOLD nanoparticles; IONIZATION (Atomic physics); SECONDARY ion mass spectrometry; LIPID analysis; PHOSPHOCHOLINE
- Publication
Surface & Interface Analysis: SIA, 2014, Vol 46, p379
- ISSN
0142-2421
- Publication type
Article
- DOI
10.1002/sia.5609