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- Title
APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.
- Authors
Khalfi, Pierre; Suspène, Rodolphe; Caval, Vincent; Thiers, Valérie; Beauclair, Guillaume; Marchio, Agnès; Bekondi, Claudine; Atsama, Marie Amougou; Camengo-Police, Serge Magloire; Noah, Dominique Noah; Njouom, Richard; Blanc, Hervé; Vallet, Thomas; Vignuzzi, Marco; Pineau, Pascal; Vartanian, Jean Pierre; Amougou Atsama, Marie; Noah Noah, Dominique
- Abstract
Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV) could be edited by APOBEC3CS188I. Using next-generation sequencing, we demonstrated that APOBEC3CS188I led to enhanced editing activity in 5'TpCpA→5'TpTpA context. This constitutes a new hallmark of this enzyme, which could be used to determine its impact on HBV or nuclear DNA.
- Subjects
HEPATITIS B; HEPATITIS viruses; GENETIC polymorphisms; HYDROLASES; RESEARCH funding; HIV; ANIMALS
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 5, p891
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac003