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- Title
Measles Vaccination Elicits a Polyfunctional Antibody Response, Which Decays More Rapidly in Early Vaccinated Children.
- Authors
Brinkman, Iris D; Butler, Audrey L; Wit, Jelle de; Binnendijk, Rob S van; Alter, Galit; Baarle, Debbie van; de Wit, Jelle; van Binnendijk, Rob S; van Baarle, Debbie
- Abstract
<bold>Background: </bold>Measles outbreaks are reported worldwide and pose a serious threat, especially to young unvaccinated infants. Early measles vaccination given to infants under 12 months of age can induce protective antibody levels, but the long-term antibody functionalities are unknown.<bold>Methods: </bold>Measles-specific antibody functionality was tested using a systems serology approach for children who received an early measles vaccination at 6-8 or 9-12 months, followed by a regular dose at 14 months of age, and children who only received the vaccination at 14 months. Antibody functionalities comprised complement deposition, cellular cytotoxicity, and neutrophil and cellular phagocytosis. We used Pearson's r correlations between all effector functions to investigate the coordination of the response.<bold>Results: </bold>Children receiving early measles vaccination at 6-8 or 9-12 months of age show polyfunctional antibody responses. Despite significant lower levels of antibodies in these early-vaccinated children, Fc effector functions were comparable with regular-timed vaccinees at 14 months. However, 3-year follow-up revealed significant decreased polyfunctionality in children who received a first vaccination at 6-8 months of age, but not in children who received the early vaccination at 9-12 months.<bold>Conclusions: </bold>Antibodies elicited in early-vaccinated children are equally polyfunctional to those elicited from children who received vaccination at 14 months. However, these antibody functionalities decay more rapidly than those induced later in life, which may lead to suboptimal, long-term protection.
- Subjects
MEASLES; IMMUNIZATION; ANTIBODY formation; RESEARCH funding; PARAMYXOVIRUSES; VIRAL antibodies; MEASLES vaccines
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 10, p1755
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab318