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- Title
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.
- Authors
Eftychi, Christina; Howson, Joanna M. M.; Barratt, Bryan J.; Vella, Adrian; Payne, Felicity; Smyth, Deborah J.; Twells, Rebecca C. J.; Walker, Neil M.; Rance, Helen E.; Tuomilehto-Wolf, Eva; Tuomilehto, Jaakko; Undlien, Dag E.; Rønningen, Kjersti S.; Guja, Cristian; Ionescu-Tîrgoviste, Constantin; Savage, David A.; Todd, John A.; Rønningen, Kjersti S; Ionescu-Tîirgovişte, Constantin
- Abstract
It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2). We were unable to confirm a recently published association of the IRS1 Gly972Arg variant with type 1 diabetes. Moreover, KCNJ11 Glu23Lys showed no association with type 1 diabetes (P > 0.05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result.
- Subjects
CANADA; EUROPE; DIABETES; GENETIC polymorphisms; GENES; CARBOHYDRATE intolerance; GENETICS; DISEASES; AMINO acids; CARRIER proteins; CELL receptors; COMPARATIVE studies; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; PHOSPHOPROTEINS; POTASSIUM; RESEARCH; TRANSCRIPTION factors; EVALUATION research
- Publication
Diabetes, 2004, Vol 53, Issue 3, p870
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.53.3.870