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- Title
Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
- Authors
Stevens, Elizabeth M.; Vladar, Eszter K.; Alanin, Mikkel C.; Christensen, Søren T.; von Buchwald, Christian; Milla, Carlos
- Abstract
The article discusses a study examining ciliary localization of the intraflagellar transport protein IFT88 that is disrupted in Cystic Fibrosis. Topics discussed include proper characteristics of secretions of mucus that trap inhaled microbial pathogens; disrupted function of the cystic fibrosis transmembrane conductance regulator (CFTR); and additional pathophysiologic mechanism for the disrupted mucociliary clearance (MCC).
- Subjects
MUCOCILIARY system; CILIA &; ciliary motion; RESPIRATORY mucosa; CYSTIC fibrosis; LUNG diseases
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2020, Vol 62, Issue 1, p120
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2018-0287le