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- Title
Oral hyaluronan relieves knee pain: a review.
- Authors
Mariko Oe; Toshiyuki Tashiro; Hideto Yoshida; Hiroshi Nishiyama; Yasunobu Masuda; Koh Maruyama; Takashi Koikeda; Reiko Maruya; Naoshi Fukui; Oe, Mariko; Tashiro, Toshiyuki; Yoshida, Hideto; Nishiyama, Hiroshi; Masuda, Yasunobu; Maruyama, Koh; Koikeda, Takashi; Maruya, Reiko; Fukui, Naoshi
- Abstract
Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.
- Subjects
THERAPEUTIC use of hyaluronic acid; KNEE pain; SYNOVIAL fluid; OSTEOARTHRITIS treatment; PSYCHOLOGY; THERAPEUTICS; CLINICAL trials; HYALURONIC acid; KNEE diseases; ORAL drug administration; OSTEOARTHRITIS; PAIN; QUALITY of life
- Publication
Nutrition Journal, 2016, p1
- ISSN
1475-2891
- Publication type
journal article
- DOI
10.1186/s12937-016-0128-2