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- Title
The Comparison of Antioxidant and Hematological Properties of N-Acetylcysteine and α-Lipoic Acid in Physically Active Males.
- Authors
Zembron-Lacny, A.; Slowinska-Lisowska, M.; Szygula, Z.; Witkowski, K.; Szyszka, K.
- Abstract
The aim of this study was to follow up whether the modification of pro-antioxidant status by oral thiol administration such as Nacetylcysteine and α-lipoic acid affects the hematological response. Twenty-eight healthy men participated in two independent experiments. Subjects were randomly assigned to one of four groups: controls (CNAC and CALA), N-acetylcysteine (NAC) and α-lipoic acid (ALA). 1200 mg of N-acetylcysteine, 600 mg of α-lipoic acid or placebo were administered for 8 days in two doses. NAC or ALA administration significantly elevated plasma total antioxidant status (TAS) and reduced protein carbonylation (PC) and lipid peroxidation (TBARS) by more than 30 %. The reduced glutathione (GSH) and hematological parameters changed only in response to NAC administration. NAC significantly elevated the level of GSH (+33 %), EPO (+26 %), Hb (+9 %) and Hct (+9 %) compared with CNAC. The mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) also increased by more than 12 % after NAC. The numerous negative or positive correlations between the measures of TAS, PC, TBARS and hematological parameters were found, which suggest the NAC-induced interaction between proantioxidant and hematological values. Our study has shown that both N-acetylcysteine and α-lipoic acid intake reveal an antioxidant action, but only N-acetylcysteine improves the haematological response.
- Subjects
CYSTEINE proteinase inhibitors; LIPOIC acid; HEMATOLOGIC agents; THIOLS; PEROXIDATION; CARBONYL compounds; GLUTATHIONE transferase
- Publication
Physiological Research, 2009, Vol 58, Issue 6, p855
- ISSN
0862-8408
- Publication type
Article