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- Title
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms.
- Authors
Huang, Keming; Luo, Xianling; Liao, Bin; Li, Guang; Feng, Jian
- Abstract
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are considered two of the most important causes of death. Experimental and clinical evidence supports the effectiveness of SGLT2i for improving cardiac dysfunction. SGLT2i treatment benefits metabolism, microcirculation, mitochondrial function, fibrosis, oxidative stress, endoplasmic reticulum stress, programmed cell death, autophagy, and the intestinal flora, which are involved in diabetic cardiomyopathy. This review summarizes the current knowledge of the mechanisms of SGLT2i for the treatment of diabetic cardiomyopathy.
- Subjects
DIABETIC cardiomyopathy; SODIUM-glucose cotransporter 2 inhibitors; HEART failure; HEART diseases; REDUCTASE inhibitors; ENDOPLASMIC reticulum
- Publication
Cardiovascular Diabetology, 2023, Vol 22, Issue 1, p1
- ISSN
1475-2840
- Publication type
Article
- DOI
10.1186/s12933-023-01816-5