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- Title
The Expression of Hypoxia-Related Biomarkers: A Significance of HIF-1a C1772T Polymorphism as Predictor of Laryngeal Carcinoma Relapse.
- Authors
Folic, Miljan M.; Banko, Ana V.; Todorovic, Vera N.; Puskas, Nela S.; Milovanovic, Jovica P.; Krejovic, Sanja B.; Dragicevic-Babic, Neda Z.; Bukumiric, Zoran M.; Milicic, Biljana R.; Jotic, Ana D.; Djukic, Vojko B.
- Abstract
Introduction: The association between the expression of HIF-1a in the laryngeal carcinoma and the prognosis of disease is quite well documented, but the significance of HIF-1a C1772T polymorphism and its relation to disease phenotype have to be clarified. The aim of this study was to investigate the influence of C1772T polymorphism on the clinical-pathological characteristics and disease-free survival after initial surgical treatment of patients with laryngeal carcinoma. Materials and methods: The prospective cohort study included 65 patients with laryngeal carcinoma. Two representative tumor tissue specimens were taken in each patient during surgery; 1 specimenwas used to assesHIF-1a C1772T polymorphism and the other 1 to determine the immunohistochemical expression of HIF-1a, VEGF, as well as CD 34 proteins. The comparison of polymorphism frequency between study and control populationwas conducted by collecting a 5mL of peripheral venous blood samples in each subject. Results: Clinicopathological characteristics of laryngeal carcinoma didn't affect the expression of hypoxia-related biomarkers, such as HIF-1a, VEGF or MVD. The statistically significant association between HIF-1a and VEGF expression was found (P = .034), but not between HIF-1a expression and MVD value (P = .696). The expression of HIF-1a was significantly higher among CT heterozygotes (P = .029). We found a significantly more recurrence among CT heterozygotes compared with patients with CC homozygous alleles (57.10% and 24.30%, respectively; P = .007). Patients with C1772T polymorphic variants had significantly worse disease-free survival compared with patients without polymorphism (Log-rank test, P = .007). Conclusion: HIF-1a C1772T polymorphism was significantly associated with worse disease-free survival which nominates it as a predictor of laryngeal carcinoma relapse. The preoperative assessment of hypoxia-related biomarkers should be used in everyday practice in order to determine the treatment modalities for laryngeal carcinoma.
- Publication
Cancer Control: Journal of the Moffitt Cancer Center, 2022, Vol 29, p1
- ISSN
1073-2748
- Publication type
Article
- DOI
10.1177/10732748221144457