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- Title
The effects of environmental factors associated with childhood urbanicity on brain structure and cognition.
- Authors
Zhang, Xiao; Yan, Hao; Yu, Hao; Zhang, Yuyanan; Tan, Hao Yang; Zhang, Dai; Yue, Weihua
- Abstract
Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors. Highlights: Urbanization is a trend lasting for more than one century, we did in-depth research which specific environment factor affects the brain structure and cognition function. Early-life rural environment was benefit for the grey matter volume (GMV) of medial prefrontal cortex, having siblings was a protective factor for MPFC GMV. Early-life urbanicity was benefit for cognition function and the GMV of total and dorsolateral prefrontal cortex, of which maternal education was a protective factor. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains.
- Subjects
BRAIN anatomy; PREFRONTAL cortex; COGNITION; REGRESSION analysis; SIBLINGS
- Publication
BMC Psychiatry, 2023, Vol 23, Issue 1, p1
- ISSN
1471-244X
- Publication type
Article
- DOI
10.1186/s12888-023-05066-3