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- Title
Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: A HuGE review and meta-analysis.
- Authors
Yong-Bin Yang; Zhan-Xue Zhao; Wei Huang; Hui Liu; Yan-Li Tan; Wei-Ming Wang; Yang, Yong-Bin; Zhao, Zhan-Xue; Huang, Wei; Liu, Hui; Tan, Yan-Li; Wang, Wei-Ming
- Abstract
<bold>Aim Of Study: </bold>To evaluate the effect of fibroblast growth factor receptor.2. (FGFR2) on genetic susceptibility for breast cancer. (BC) in Chinese populations.<bold>Materials and Methods: </bold>A computerized literature search was carried out in PubMed, Chinese Biomedical Database. (CBM), and Chinese National Knowledge Infrastructure. (CNKI) to collect relevant articles. Pooled odds ratio. (OR) and 95% confidence interval. (CI) were used to assess the strength of the associations.<bold>Results: </bold>A total of 21 articles involving a total of 15 polymorphisms of the FGFR2 gene were included in the meta-analysis. Due to the limited studies for rs17102287, rs2981578, rs3135718, rs3803662, rs3750817, rsl0510097, rsl7542768, rs13387042, and rs1982073; we only pooled the six polymorphisms. (rs11200014, rs1219648, rs2420946, rs2912778, rs2981579, and rs2981582) into this meta.<bold>Analysis: </bold>Overall, significantly increased BC risk was associated with five polymorphisms. (rs2981579, rs2981582, rs1219648, rs2420946, and rs2912778) when all studies were pooled into the meta.<bold>Analysis: </bold>When stratified by ethnicity and source of controls, similar results were also detected. However, for rs2981579 no significant association was found among Chinese Han in all genetic models.<bold>Conclusion: </bold>Our meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of BC. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.
- Subjects
BREAST cancer risk factors; FIBROBLAST growth factor 2; GENETIC polymorphisms; BREAST cancer patients; SINGLE nucleotide polymorphisms
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 2, p543
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.148715