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- Title
Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus.
- Authors
Wu, Chien-Sheng; Hu, Chung-Yi; Chan, Cheng-Ju; Chang, Sheng-Kai; Hsu, Ping-Ning
- Abstract
The growth arrest-specific 6 ( GAS6) gene product participates in platelet activation and granulocyte interaction with the endothelium. Our case-control study aimed to determine whether polymorphism of GAS6 was associated with predisposing risk or specific clinical manifestations of systemic lupus erythematosus (SLE). Two of the single-nucleotide polymorphisms (SNPs) of the GAS6 gene, GAS6 834 + 7G/A (rs8191974) and GAS6 +1332C/T (rs1803628), were investigated in 83 SLE patients and 89 non-lupus control subjects. We demonstrated that among lupus patients, the GAS6 +1332 T allele was more prevalent in patients with cutaneous vasculitis (allele T 41.7 % in patients with cutaneous vasculitis compared with 18.3 % in patients without vasculitis, odds ratio (OR) 3.2, 95 % confidence interval 1.3-8.0, p = 0.016). In conclusion, GAS6 polymorphism is positively associated with cutaneous vasculitis in SLE patients, which suggests that GAS6 polymorphism could be a genetic marker for SLE with cutaneous vasculitis.
- Subjects
GENETIC polymorphisms; VASCULITIS; SYSTEMIC lupus erythematosus; TAIWANESE people; BLOOD platelet activation; GRANULOCYTES; ENDOTHELIUM; PATIENTS; DISEASES
- Publication
Clinical Rheumatology, 2012, Vol 31, Issue 10, p1443
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-012-2027-z