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- Title
Impact of Androgen Receptor Gene Expression in Gastric Cancer: a Meta-Analysis Based on the GEO Database, TCGA Database, and Literature.
- Authors
Li, Huafu; Wei, Zhewei; Wang, Chunming; Chen, Wei; He, Yulong; Zhang, Changhua
- Abstract
To evaluate androgen receptor and AR gene expression impact of gastric cancer (GC). Meta-analysis of microarray data obtained from the Gene Expression Omnibus (GEO) database, TCGA (The Cancer Genome Atlas) database, and data by systematic search of PubMed, China National Knowledge Internet and Web of Science. This meta-analysis included 30 studies involving 4487 patients. From our results, we can know that the positive rate of AR expression in gastric cancer is 40%. The expression of AR was significantly higher in men (SWD = 1.00, 95% CI 0.03 ~ 1.96, P = 0.042). The higher AR expression was linked with poor over survival (OS) (HR = 1.30, 95% CI 1.13 ~ 1.49, P < 0.0001). AR gene may be an important factor affecting the poor prognosis of GC patients of different genders.
- Subjects
CHINA; STOMACH tumors; ONLINE information services; SURVIVAL; META-analysis; CONFIDENCE intervals; SYSTEMATIC reviews; INTERNET; GENE expression; INTELLECT; DESCRIPTIVE statistics; ANDROGEN receptors; MEDLINE
- Publication
Indian Journal of Surgery, 2022, Vol 84, Issue 1, p28
- ISSN
0972-2068
- Publication type
Article
- DOI
10.1007/s12262-020-02168-0