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- Title
Sequential Hydroformylation/Diels-Alder Processes: One-Pot Synthesis of Polysubstituted Cyclohexenes, Cyclohexadienes, and Phthalates from Alkynes.
- Authors
Fang, Xianjie; Jackstell, Ralf; Beller, Matthias
- Abstract
A novel, one-pot hydroformylation/Diels-Alder sequence for the synthesis of multisubstituted cyclohexenes, cyclohexadienes, and phthalates has been developed. Various alkynes were efficiently converted into the corresponding products in good yields and with excellent diastereoselectivity through palladium-catalyzed hydroformylation followed by an AAD-type reaction (AAD: Amides-Aldehydes-Dienophiles). In view of the availability of the substrates, the atom-efficiency of the overall process, and the convenient introduction of substituents in the cyclohexene ring, this method complements current methods for the preparation of polysubstituted cyclohexane derivatives.
- Subjects
FORMYLATION; CHEMICAL synthesis; CYCLOHEXENE; ALKYNES; STEREOSELECTIVE reactions; CYCLOHEXANE
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 26, p7939
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201402981