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- Title
Triazole-Tailored Guanosine Dinucleosides as Biomimetic Ion Channels to Modulate Transmembrane Potential.
- Authors
Kumar, Y. Pavan; Das, Rabindra Nath; Kumar, Sonu; Schütte, Ole Mathis; Steinem, Claudia; Dash, Jyotirmayee
- Abstract
A 'click' ion channel platform has been established by employing a clickable guanosine azide or alkyne with covalent spacers. The resulting guanosine derivatives modulated the traffic of ions across the phospholipid bilayer, exhibiting a variation in conductance spanning three orders of magnitude (pS to nS). Förster resonance energy transfer studies of the dansyl fluorophore with the membrane binding fluorophore Nile red revealed that the dansyl fluorophore is deeply embedded in the phospholipid bilayer. Complementary cytosine can inhibit the conductance of the supramolecular guanosine channels in the phospholipid bilayers.
- Subjects
TRIAZOLES; GUANOSINE; ION channels; BILAYER lipid membranes; FLUORESCENCE resonance energy transfer; CYTOSINE
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 11, p3023
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201304530