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- Title
Analysis of CD34+ cell collection using two mobilization regimens for newly diagnosed multiple myeloma patients reveals the separate impact of mobilization and collection variables.
- Authors
Abuabdou, Ahmed; Rosenbaum, Eric R.; Usmani, Saad Zafar; Barlogie, Bart; Cottler‐Fox, Michele
- Abstract
Mobilization regimens for CD34+ cells have generally been judged successful based on the number of cells collected without evaluating mobilization separately from collection. Using retrospective data for patients who collected CD34+ cells on Total Therapy protocols 3a/3b (VTD-PACE) and Total Therapy 4/5 using a novel regimen that added low dose melphalan to VTD-PACE (MVTD-PACE), we analyzed mobilization and collection variables separately. A significant difference favoring MVDT-PACE was found in mean CD34+ cells/µL on day 2 of collection and in mean ratio of CD34+ cells/µL on day 2 to day 1. However, because apheresis variables and growth factor dose during collection were manipulated to optimize individual collections, the two regimens were not significantly different when the mean total CD34+ cells ×106/kg collected was compared. Thus, when evaluating a chemotherapy regimen or new growth factor for mobilization, it is important to realize that total CD34+ cells collected is dependent on both mobilization and collection variables. J. Clin. Apheresis 29:251-255, 2014. © 2013 Wiley Periodicals, Inc.
- Publication
Journal of Clinical Apheresis, 2014, Vol 29, Issue 5, p251
- ISSN
0733-2459
- Publication type
Article
- DOI
10.1002/jca.21313