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- Title
Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T<sub>1</sub> and area.
- Authors
Brief, E. E.; Vavasour, I. M.; Laule, C.; Li, D. K. B.; MacKay, A. L.
- Abstract
The T1 values of metabolites were measured in eight subjects with clinically definite multiple sclerosis (MS) having at least one large brain lesion (2.6 ± 0.7 mL) and in eight age- and sex-matched healthy controls. MRS examinations were conducted at 1.5 T using point-resolved spectroscopy (PRESS) (TE = 30 ms, TR = 530, 750, 1200, 1500, 3500, 5000 ms). Spectra were acquired from a voxel placed in the largest lesion in the subject with MS, and in a corresponding voxel (same size and region) in normal white matter (NWM) in the matched control, and were fitted using LCModel. As there are regional variations in metabolite and water T1 and metabolite signal areas, careful placement of the control voxel was necessary to measure subtle differences between the lesions and NWM. The T1 and T1-corrected signal areas of creatine were the same in MS lesions as in controls. The T1 values of choline were significantly shorter in MS lesions located in occipital and parietal, but not in frontal, white matter. N-Acetylaspartate (NAA) and myoinositol T1 values in MS lesions were similar to those in NWM; however, the area of myoinositol correlated directly with lesion water T1, and the area of NAA correlated inversely with lesion water T1. MR spectra acquired at short TR require T1 correction of choline for accurate quantification. Careful voxel placement in controls to match lesion location in subjects with MS enables a clearer view of the subtle changes in lesions. Copyright © 2010 John Wiley & Sons, Ltd.
- Publication
NMR in Biomedicine, 2010, Vol 23, Issue 9, p1033
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.1527