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- Title
Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre-screening of 5-HT<sub>1A</sub> ligands.
- Authors
PaweŁ Zajdel; Andrzej J. Bojarski; Hanna Byrtus; Grażyna ChŁoń-Rzepa; Jolanta Obniska; Pierre Chevallet; Jean Martinez; Maciej PawŁowski
- Abstract
Chromatographic parameters (ΔRf), defined as a difference in the migration of tested compound on the control and peptide impregnated silica gel TLC plates, were determined for 42 arylpiperazine derivatives. An amino acid sequence of the peptide used for impregnation was derived from the III transmembrane segment of the 5-HT1A receptor in the close vicinity of aspartic acid (Asp 166) residue. It was found that the ΔRf values obtained in a model employing tetrapeptide P4LA (ADVL), as well as the calculated logP correlate with 5-HT1A receptor affinity of the studied compounds. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
PEPTIDES; ASPARTIC acid; EXCITATORY amino acids; ASPARTAME; PROTEINS
- Publication
Biomedical Chromatography, 2003, Vol 17, Issue 5, p312
- ISSN
0269-3879
- Publication type
Article
- DOI
10.1002/bmc.224