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- Title
Quantitative assessment of hyperacute cerebral infarction with intravoxel incoherent motion MR imaging: Initial experience in a canine stroke model.
- Authors
Gao, Qian‐Qian; Lu, Shan‐Shan; Xu, Xiao‐Quan; Wu, Cheng‐Jiang; Liu, Xing‐Long; Liu, Sheng; Shi, Hai‐Bin; Gao, Qian-Qian; Lu, Shan-Shan; Xu, Xiao-Quan; Wu, Cheng-Jiang; Liu, Xing-Long; Shi, Hai-Bin
- Abstract
<bold>Purpose: </bold>To evaluate the feasibility of intravoxel incoherent motion (IVIM) for the measurement of diffusion and perfusion parameters in hyperacute strokes.<bold>Materials and Methods: </bold>An embolic ischemic model was established with an autologous thrombus in 20 beagles. IVIM imaging was performed on a 3.0 Tesla platform at 4.5 h and 6 h after embolization. Ten b values from 0 to 900 s/mm2 were fitted with a bi-exponential model to extract perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D*. Additionally, the apparent diffusion coefficient (ADC) was calculated using the mono-exponential model with all the b values. Statistical analysis was performed using the pairwise Student's t test and Pearson's correlation test.<bold>Results: </bold>A significant decrease in f and D was observed in the ischemic area when compared with those in the contralateral side at 4.5 h and 6 h after embolization (P < 0.01 for all). No significant difference was observed in D* between the two sides at either time point (P = 0.086 and 0.336, respectively). In the stroke area, f at 6 h was significantly lower than that at 4.5 h (P = 0.016). A significantly positive correlation was detected between ADC and D in both stroke and contralateral sides at 4.5 h and 6 h (P < 0.001 for both). Significant correlation between ADC and f was only observed in the contralateral side at 4.5 h and 6 h (P = 0.019 and 0.021, respectively).<bold>Conclusion: </bold>IVIM imaging could simultaneously evaluate the diffusion and microvascular perfusion characteristics in hyperacute strokes.<bold>Level Of Evidence: </bold>2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:550-556.
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 2, p550
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25556