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- Title
Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9.
- Authors
Liu, Yu-Jing; Zhang, Jian-Long; Li, Chen; Mu, Xue-Gen; Liu, Xiao-Li; Wang, Lei; Zhao, Yan-Cui; Zhang, Peng; Li, Xiao-Dong; Zhang, Xing-Xiao; Leon, Francisco
- Abstract
Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 μg/mL.
- Subjects
METABOLITES; PATHOGENIC bacteria; QUANTUM computing; STREPTOCOCCUS pneumoniae; ASPERGILLUS; STAPHYLOCOCCUS aureus; FUNGI
- Publication
Molecules, 2019, Vol 24, Issue 24, p4596
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24244596