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- Title
Systematic Studies on the Protocol and Criteria for Selecting a Covalent Docking Tool.
- Authors
Wen, Chang; Yan, Xin; Gu, Qiong; Du, Jiewen; Wu, Di; Lu, Yutong; Zhou, Huihao; Xu, Jun
- Abstract
With the resurgence of drugs with covalent binding mechanisms, much attention has been paid to docking methods for the discovery of targeted covalent inhibitors. The existence of many available covalent docking tools has inspired development of a systematic and objective procedure and criteria with which to evaluate these programs. In order to find a tool appropriate to studies of a covalently binding system, protocols and criteria are proposed for protein–ligand covalent docking studies. This paper consists of three sections: (1) curating a standard data set to evaluate covalent docking tools objectively; (2) establishing criteria to measure the performance of a tool applied for docking ligands into a complex system; and (3) creating a protocol to evaluate and select covalent binding tools. The protocols were applied to evaluate four covalent docking tools (MOE, GOLD, CovDock, and ICM-Pro) and parameters affecting covalent docking performance were investigated.
- Subjects
TECHNICAL specifications; MICROSOFT Surface (Computer); ACCELEROMETERS; PROTEIN binding; DRUG design
- Publication
Molecules, 2019, Vol 24, Issue 11, p2183
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24112183