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- Title
Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents.
- Authors
Tian, Yu; Cao, Xiao-Xue; Shang, Hai; Wu, Chong-Ming; Zhang, Xi; Guo, Peng; Zhang, Xiao-Po; Xu, Xu-Dong; Drasar, Pavel B.; Khripach, Vladimir A.
- Abstract
A series of novel caffeoylquinic acid derivatives of chlorogenic acid have been designed and synthesized. Biological evaluation indicated that several synthesized derivatives exhibited moderate to good lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 3d, 3g, 4c and 4d exhibited more potential lipid-lowering effect than the positive control simvastatin and chlorogenic acid. Further studies on the mechanism of 3d, 3g, 4c and 4d revealed that the lipid-lowering effects were related to their regulation of TG levels and merit further investigation.
- Subjects
PHENYLPROPANOIDS; ANTILIPEMIC agents; CHLOROGENIC acid; CHEMICAL derivatives; OLEIC acid
- Publication
Molecules, 2019, Vol 24, Issue 5, p964
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24050964