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- Title
Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities.
- Authors
Cardoso, Mariana F. do C.; Gomes, Ana T. P. C.; Moreira, Caroline dos S.; Simões, Mário M. Q.; Neves, Maria G. P. M. S.; da Rocha, David R.; da Silva, Fernando de C.; Moreirinha, Catarina; Almeida, Adelaide; Ferreira, Vitor F.; Cavaleiro, José A. S.
- Abstract
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b-g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus.
- Subjects
POVIDONE; CATALYTIC oxidation; MANGANESE compounds; CHEMICAL synthesis; ANTIBACTERIAL agents; HYDROGEN peroxide synthesis; SULFONYL compounds
- Publication
Molecules, 2017, Vol 22, Issue 2, p302
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22020302