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- Title
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR.
- Authors
Xiangchen Huang; Min Dong; Jian Liu; Kehui Zhang; Zhenjun Yang; Liangren Zhang; Lihe Zhang
- Abstract
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N¹,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.
- Subjects
ADENOSINE diphosphate; RYANODINE receptors; CONDENSATION; MOLECULES; ACYCLIC acids
- Publication
Molecules, 2010, Vol 15, Issue 12, p8689
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15128689