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- Title
Reconstruction of Ligament and Tendon Defects Using Cell Technologies.
- Authors
Chailakhyan, R.; Shekhter, A.; Ivannikov, S.; Tel'pukhov, V.; Suslin, D.; Gerasimov, Yu.; Tonenkov, A.; Grosheva, A.; Panyushkin, P.; Moskvina, I.; Vorob'eva, N.; Bagratashvili, V.
- Abstract
We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.
- Subjects
LIGAMENTS; ACHILLES tendon injury treatment; REGENERATION (Biology); STROMAL cells; TISSUE engineering; BLOOD vessels
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 4, p563
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3660-y