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- Title
Angiogenic Effects of Dimeric Dipeptide Mimetic of Loop 4 of Nerve Growth Factor.
- Authors
Kryzhanovskii, S.; Antipova, T.; Tsorin, I.; Pekeldina, E.; Stolyaruk, V.; Nikolaev, S.; Sorokina, A.; Gudasheva, T.; Seredenin, S.
- Abstract
Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly ( p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic activity was not inferior to the reference neurotrophin NGF. In experiments with hindlimb ischemia modeled in rats, GK-2 (1 mg/kg intraperitoneally for 14 days) significantly increased the total length of capillary vessels ( p<0.003) and the number of vessels per 1 mm2 ischemic tissue ( p<0.001) in comparison with the control. Our findings indicate that under experimental conditions compound GK-2 exhibits not only angiogenic, but also anti-ischemic activity.
- Subjects
VASCULAR endothelial growth factors; CYTOKINES; GROWTH factors; PEPTIDES; APIDAECINS
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 161, Issue 4, p513
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3450-y