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- Title
Neuropeptide Cycloprolylglycine Exhibits Neuroprotective Activity after Systemic Administration to Rats with Modeled Incomplete Global Ischemia and in In Vitro Modeled Glutamate Neurotoxicity.
- Authors
Povarnina, P.; Kolyasnikova, K.; Nikolaev, S.; Antipova, T.; Gudasheva, T.
- Abstract
We studied cerebroprotective properties of neuropeptide cycloprolylglycine (1 mg/kg) administered intraperitoneally to rats with modeled incomplete global ischemia rats and neuroprotective properties for HT-22 cells under conditions of glutamate toxicity. It was shown that the neuropeptide administered during the postischemic period restored the neurological status of rats by preventing sensorimotor impairments in the limb-placing test and suppression of locomotor activity in the open field test. In in vitro experiments, cycloprolylglycine in concentrations of 10-10 M exhibited pronounced dose-dependent neuroprotective activity. The results attest to high cerebro- and neuroprotective potential of endogenous peptide cycloprolylglycine.
- Subjects
NEUROPEPTIDES; NEUROTOXICOLOGY; ISCHEMIA; BLOOD circulation disorders; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 160, Issue 5, p653
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3241-5